报告题目：Chemical Biology Approaches in Target ValidationChemical Biology Approaches in Target Validation
报告人：杨财广 研究员
报告时间：2014年9月25日（星期四）下午2：00
报告地点：j9九游会(中国)官方网站中北校区化学馆A-205报告厅
报告人简介：2008–present, Professor of Chemistry (the 100-Talent Program), Shanghai Institute of Materia Medica;
2002–2008, Postdoctoral, University of Chicago;
1997–2002, PhD in organic chemistry, Shanghai Institute of Organic Chemistry;
1993–1997, BS in chemistry, Huazhong University of Science and Technology.
报告内容： Our research has been focused on “protein structure and function and its regulation through chemicals” in the direction of "chemical probe and target validation", which is a cutting research in the field of Chemical Biology. We have uncovered the molecular mechanisms and chemical regulations of several important proteins, which interact with biological macromolecules, including nucleic acid demethylases, redox-sensing transcriptional regulators, and virulence factors by using small molecule tools. These studies thus help to understand the biological pathways better, and obtain active compounds as well as target candidates for drug discovery.