报告题目：Inducible DNA Cross-Linking Agents and their Medical Application
报告人：Dr. Xiaohua Peng
报告时间：2015年6月23日（星期二）下午3:00
报告地点：j9九游会(中国)官方网站闵行校区化学系135报告厅
主持人：黄琨
报告人简介：Dr. Xiaohua Peng is an Associate Professor in the Department of Chemistry and Biochemistry at the University of Wisconsin Milwaukee. She received a Ph.D. from the Osnabrueck University in Germany in 2006. She was a recipient of Chinese Government Award for Outstanding Self-financed Students Abroad. After completing her PhD, she joined the Department of Chemistry at the Johns Hopkins University (Baltimore, MD, USA) for postdoc training from Nov. 2006 to Jul. 2009. Dr. Peng became an Assistant Professor at the University of Wisconsin Milwaukee (UWM) in 2009 and she is the founding faculty member of UWM's Milwaukee Institute for Drug Discovery. She has published over 50 papers in peer-reviewed journals, plus 2 book chapters, 3 invited reviews, and 6 issued patents. She received the Greater Milwaukee Foundation's Shaw Scientist Award in 2012, which recognizes the importance, impact, and potential of her contributions to cancer research. She was also a recipient of the Graduate School/UWM Foundation Research Award. Dr. Peng’s lab is currently funded by the National Institutes of Health, Greater Milwaukee Foundation, Bradley foundation, and Wisconsin Applied Research Grant. Dr. Peng’s major research interest focus on inducible biopolymer cross-linking agents and their medical application.
报告内容简介：Dr. Peng will discuss a new strategy for improving the selectivity of anticancer drugs and decreasing the side effects by using DNA cross-linking agents that are activated by trademark conditions inside cancer cells – increased oxidative stress and hypoxia. This methodology embraces cancer-targeting strategies and novel chemistry design to develop new DNA cross-linking agents that are attracted only to the cancer. A series of boron-based DNA cross-linking agents have been discovered to be activated by H2O2 that is considered as one of the most common reactive oxygen species in cancer cells. These agents are not active by themselves but can selectively react with H2O2 to release active species alkylating or cross-linking DNA or proteins. In vitro cytotoxicity assays showed that these agents were not toxic towards normal cells but greatly inhibited cancer cell growth. The efficacy and selectivity were further investigated in normal mice and Xenograft breast cancer models. The details of the chemistry and implications will be discussed.